The last time the clinic spoke to an Acell director with a view to use and test the product they told us at present they could not supply to doctors in the European Union as it had not been given a "CE" mark. It had been cleared for use by veterinarians for use on animals within the EU but not by doctors for use on humans. They hoped to have is passed but were still waiting........... European Parliament bureaucracy at it's best maybe
The story goes like this: When a hobby-store owner in Cincinnati sliced off his fingertip in 2005 while showing a customer why the motor on his model plane was dangerous, he went to the emergency room without the missing tip. He couldn't find it anywhere. The doctor bandaged the wound and recommended a skin graft to cover the top of his right-middle stub for cosmetic purposes, since nothing could be done to rebuild the finger. Months later, he had regrown it, tissue, nerves, skin, fingernail and all.
http://health.howstuffworks.com/extracellular-matrix.htm The hobbyist lost only his finger tip at the lower part of the nail and not the entire finger. But how was he able to regrow it? It turns out that he has a brother in the tissue-regeneration business that encouraged him to apply a powdered extract from pig's bladder to the raw finger tip instead of undergoing the skin graft. The extract was extracellular matrix (ECM), which is composed of collagen. It lays the necessary framework that cells use to generate body parts.
Origins and function of ECM All animals have ECM, a component of body tissue, which provides signals that direct cells to divide, differentiate, and develop into a specific form. Under the influence of ECM, salamanders regrow limbs, deer grow new antlers, and a human fetus grows and regrows body parts. ECM works in conjunction with stem cells in a developing fetus to produce (and reproduce) body parts in the womb but stops functioning when the fetus is fully grown.
Evidence suggests that the application of ECM from a pig can stimulate regrowth of select body parts in humans. Pig bladders are an efficient source of ECM extracts because they are a throw away product in the agricultural community. The pig extract is also used on horses to repair torn ligaments and in people with ulcers to repair holes in the stomach lining. ECM is found outside of the body s cells so the pig bladder extract does not actually have any of the pig's cells in it.
ECM works differently than the normal healing mechanism. For example, when the hobbyist injured his fingertip, the cells immediately started to die and their contents leaked into surrounding tissue. Signals alerted the immune system to respond with inflammation and, subsequently, development of scar tissue. The scar tissue prevents cellular regrowth in the injured area and it lasts forever because cells cannot repair the skin. But ECM, such as what the hobbyist used, does not trigger an immune response. It causes the cells in the tissue surrounding the wound to repair the damage in the same way they would in a developing fetus. The cells then divide and regrow new tissue, not scar tissue.
ECM could grow just about every tissue in the body. Medical doctors at the University of Pittsburgh treated a patient with regenerative ECM therapy since he was too weak to undergo surgery for his esophageal cancer. They removed the cancerous lining of the esophagus and inserted ECM, which instructed new cells to grow a new lining instead of forming scar tissue that could block the organ from functioning. The procedure was successful and today the patient has a new esophagus and is cancer fee. The doctors also transplanted the hand from a cadaver onto the arm of a military man who lost his right hand while working with dynamite. They used cell therapy and a bone marrow transplant to get his body to accept the new hand instead of using toxic immunosuppressive drugs.
Biotech companies and the government are funding research in regenerative medical science with a goal to help burn victims, people who are on the long waiting list for organ transplants, and the veterans of the Iraq and Afghanistan Wars who were badly maimed. So far, research has produced hearts, ears, kidneys, lungs, and bladders by manipulating body cells to regrow tissue. Growing organs involves creating a 3-D mold of the body part and layering it with cells. The process takes 6 to 8 weeks and human testing of heart valves and blood vessels are scheduled to begin within 5 years. Nine patients so far have received new bladders grown from their own cells outside of the body helping them to live normal lives. Some regenerative scientists are trying to trick the body into repairing itself but it s a matter of finding the internal switch that tells cells to grow like that which occurs while we are still in the womb.
Regenerative medical scientists have brought this technology to the next level and are running clinical trials. It is uncertain if ECM in humans can function in a regenerative capacity like it does in a developing fetus. There may be an internal switch in humans that activates ECM to regrow body parts such as it does in the womb. Finding and activating that switch could lead to cures for spinal injuries, amputated limbs, and damaged organs.