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Of greatest interest to those with androgenetic alopecia is evidence that green tea can influence serum concentrations of hormones and inhibit TNF-a. Research in this area is primarily with reference to hormonal effects on the development of cancer and how green tea and other caffeine containing products might mediate changes in hormone levels. For example, high intake of Green tea has been associated with higher levels of sex hormone binding globulin (SBHG) and lowered levels of serum estradiol (estrogen) concentration in women (Nagata 1998). Increased SBHG may be of help in reducing the effects of androgenetic alopecia. SBHG is a molecule that binds with high affinity to testosterone. Testosterone bound to SBHG is not bioactive and cannot bind to androgen receptors or be converted into dihydrotestosterone. An increase in SBHG concentration effectively reduces free testosterone. Green tea may also have an affect on the type I 5 alpha reductase enzyme that converts testosterone to dihydrotestosterone. These two distinct, but complementary, effects of green tea may influence androgenetic alopecia.
One cup of green tea roughly equals 50 mg of tea catechins. Typically research investigations have involved individuals drinking six cups of green tea, or utilizing Green Tea Extracts (300mg or more catechins) each day. Green tea is well tolerated by most individuals with no significant side effects reported