Update at +24 weeks:
Top view, just after exosome treatment -the hair is soaked by the product :
View from above, after the shampoo and towel-dried but still wet hair the next day :
Updated May 2024: As mentioned in the previous text, the ASCE+ HRLV product is based on plant-derived exosomes (rose). After 20 weeks of treatment, it brought me a little benefit but nothing extraordinary... so I decided to change the product. I now move on to the following products that rely on human sources:
- AAPE Hair (ABIO material): These are secretomes derived from human adipose tissue.
- Exosomes for hair (Creative Biolab): These are exosomes from human umbilical cord.
For information, AAPEs are not ASC-EXOs (exosomes from adipose stem cells) but ASC-CMs (conditioned media from adipose stem cells), called secretomes.
ASC-CM is a complex cocktail of proteins, nucleic acids, and lipids released as soluble factors and/or transported in extracellular vesicles (EVs). The difference between secretome molecules lies mainly in the size of their particles. Microvesicles are larger, approximately 150–1000 μm, while exosomes are smaller, approximately 30–150 μm. Exosomes therefore penetrate the skin better.
Secretome and exosomes are sometimes used synonymously, but they are actually different.
The secretome is the collection of all messenger substances released to the outside, including microvesicles and exosomes, but also other important factors dissolved in the liquid. These include many growth factors that promote regeneration and so-called cytokines (cell-cell messengers).
Exosomes, on the other hand, are actually just particulate exosomes isolated from the whole thing. Isolation concentrates them, but important solutes and microvesicles are lost.
In my opinion, exosomes carry more microRNAs than secretomes because they are more filtered and can therefore stimulate, for example, the wnt/beta-catenin pathway which is very important for hair loss.
So I'm going to continue taking exosomes, but now also adding AAPE and making sure the sources are human and not plant-based. I take this combo because I think microRNAs are important in addition to the various proteins/growth factors.
You will find the list of microRNAs found in exosomes from adipose tissue and umbilical cord in this research paper: "Systemic proteomics and miRNA profile analysis of exosomes derived from human pluripotent stem cells". By comparing them with the list of microRNAs which have an impact on hair (see this research paper : "Perspectives on miRNAs Targeting DKK1 for Developing Hair Regeneration Therapy"), it seems that there are more of them than in the exosomes from rose... which is a good point !
