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INDIVIDUAL RESEARCHERS

Bigmac

Bigmac

Administrator
Staff member
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ARI

Ken Washenik, MD, PhD
Executive VP,
Scientific and Medical Development
Ken is the former Director of the Dermatopharmacology unit at the New York University School of Medicine. He also serves as Medical Director of Bosley.

Kurt Stenn, MD
Vice President and Chief Scientific Officer
Dr. Stenn is one of the nation's preeminent scholars in the area of hair follicle research. He previously served for 10 years as the Director of Skin Biology at Johnson and Johnson. Prior to that, he was a full professor at Yale University for 20 years, as well as Director of Dermatopathology Laboratory Services at Yale.

Thomas Barrows, PhD
Technical Director Tom is a biomaterials polymer chemist with extensive experience in the field of tissue engineering. He has more than 20 years experience at 3M Corporation as a Senior Research Chemist.

ICXTRC

Paul Kemp BSc, PhD, Founder and Chief Scientific Officer

Paul founded Intercytex in 1999 and is its Chief Scientific Officer. He has over 17 years of experience in the commercial development of cell therapy. Prior to founding Intercytex, he was VP Research at Organogenesis Inc. He is a principal inventor on several patents related to regenerative medicines including the wound repair stimulant, Apligraf ®.

John St Clair Roberts MRCS, LRCP, FFPM, Vice President - Medical Affairs

John joined Intercytex as VP Medical Affairs in September 2005 with over 20 years of experience in the clinical development of vaccines and biological products. Previously, he held the position of Medical Director at a number of leading biotechnology companies including Microscience plc, Xenova Group plc, Cantab Pharmaceuticals plc and Merieux UK. John graduated in medicine from the Royal College of Surgeons in Ireland and prior to his career in industry he practised hospital medicine.

Mike Leek PhD, MBA, Vice President - Operations

Mike joined Intercytex in 2000 as Commercial Director and has been VP Operations since January 2005. Mike has over 15 years of experience in commercial woundcare and cell therapy. Prior to Intercytex he was with Smith & Nephew Group Research running the tissue repair programme, identifying and developing products for the woundcare and orthopaedic markets including a joint venture with Advanced Tissue Sciences in the development of Dermagraft ®, a cell therapy woundcare product.

ISOLAGEN

Dr. Marie Lindner
Dr. Marie Lindner was appointed Senior Vice President of Medical and Business Affairs in July 2005. Prior to joining Isolagen, Dr. Lindner served as Vice President of Strategic Development at BTG International, where she was responsible for acquisitions, developments and licensing of medical devices and other life science products, including a wound debridement product. Dr. Lindner spent 1991-1998 at Rhone-Poulenc Rorer (RPR) (now Sanofi-Aventis) where she held a number of executive positions pf escalation responsibility from Assistant Director of Clinical Development to Executive Director, Business Development and Licensing. During her time at RPR, Dr. Lindner spent four years at Gencell, RPR €™s gene and cell therapy division. Dr. Lindner joined SmithKlineBeechan) now Glaxo SmithKline) where she was Global Director of Business Development. Later she joined Elan, where she was Vice President of medical Market Strategy in the Drug Delivery division.

HAIR SCIENCE INSTITUTE

Dr. Coen Gho
Technology based on the follicular stem cells and not on the Dermal Papilla cells as allegedly Intercytex/Aderans research.World Trade Center Amsterdam
Strawinskylaan 157
1077 XX Amsterdam
Tel: +31 (0)20 575 2330
Fax: +31 (0)20 575 2331
Medisch Centrum Wittevrouwenhof Maastricht
Wethouder van Caldenborghlaan 45
6226 BS Maastricht
Tel: +31 (0)43 6018100
Fax: +31 (0)43 6018109
http://www.hairscienceinstitute.com/

HOWARD HUGHES MEDICAL INSTITUTE

Elaine Fuchs, Ph.D.
Rebecca C. Lancefield Professor and Head of the Laboratory of Mammalian Cell Biology and Development
Investigator, Howard Hughes Medical Institute
How do stem cells €œknow € their fate?
Elaine Fuchs studies the cell biology, genetics and development of skin and hair. Her basic research on the molecular mechanics underlying development and differentiation of these tissues addresses one of the fundamental questions underlying stem cell biology: How do stem cells €œknow € their fate? When scientists understand the factors that determine whether a stem cell develops into a heart cell rather than a skin cell or another type of body cell, they will be better equipped to design cell-based treatments for specific medical conditions.
Unlike stem cells for many other tissues, skin stem cells from an adult human or animal can be cultured easily in the lab (so easily, in fact, that the process is used in treating burn victims). With these cultures Fuchs and her colleagues study how the multipotent (able to differentiate into cells of the same tissue) stem cells of the skin of humans, rodents and other mammals give rise to the epidermis and hair follicles.
Fuchs €™ basic research also may elucidate the molecular basis of skin cancers, psoriasis, blistering diseases and other disorders, even ones extending beyond skin. Among her discoveries is the genetic basis of a type of skin tumor that affects the scalp. Because of the extraordinary self-regenerating properties of stem cells, Fuchs hypothesizes that stem cell errors are a likely cause of many types of human cancers. Through research on stem cells, she hopes to understand the genetics of squamous and basal cell carcinomas, the most common types of human cancers in the world.
Scientists led by Fuchs have made several key discoveries about the biology of skin and hair stem cells. In 2003, Fuchs reported that two proteins work in concert to guide a stem cell to become a hair follicle rather than skin. These two proteins help change the stem cell €™s shape so that it can separate from adjoining cells and move downward €” a developmental step that is essential for a hair follicle to form from a stem cell. One of these proteins, called Wnt, has already been implicated in the spread of some cancers, such as colon and breast cancer. Fuchs believes that the same process that leads to the separation of a stem cell from other cells may shed insight into how a cancer cell metastasizes, or spreads, from its host tumor.
Fuchs and her colleagues also developed a new method to track and isolate skin and hair stem cells, a technique that may also be valuable in searching for stem cells that produce the cells of the heart, pancreas and other specific body tissues.

University of Melbourne Dermatology Dept

Stephen Harrap
The genetics of androgenetic alopecia

Androgenetic alopecia (AGA),often referred to as pattern or common baldness, is a condition that requires genetic predisposition and the presence of androgens. It occurs in men and women, although it is unclear as to whether male and female AGA are identical conditions. The genetic basis of AGA remains largely unknown. We have performed a number of case-control genetic association studies using participants of the VFHS, concentrating thus far on candidate genes related to the sex steroid pathways. Our group was the first in the world to demonstrate the association of the first gene, the androgen receptor (AR),with common male baldness (Ref 6),a finding that was recently replicated by other international investigators. We are continuing to define this association, and track down the exact DNA variants in this gene that contribute to hair loss in men. We are also investigating the role of this gene and others in common female balding in collaboration with Professor Rodney Sinclair, University of Melbourne Department of Dermatology, St Vincent €™s Hospital.

Lu Zhongfa

Department of Dermatology
The Second Affiliated Hospital,
College of Medicine, Zhejiang University,
Hangzhou 310009, China
EDUCATION:
Aug. 1982- July 1985: Medical student of The JingHua Medical College Zhejiang Province, China.
Aug. 1990 - July 1993: Candidate for MD in Department of Dermatology, Xin Qiao Hospital of The Third Military Medical University. Chongqing, China
Aug. 1995 - Aug 1998: Candidate for Ph.D. in Department of Dermatology, Southwest Hospital of the Third Military Medical University. Chongqing, China
Work History:
1 Aug 1985--Aug 1990. Residency, physcian and attending doctor, in Department of internal medicine, JinHua Worker Hospital, ZheJiang Province, P R China.
2 Aug 1993--Aug 1995. Attending doctor in Department of Dermatology, Xin Qiao Hospital of The Third Military Medical University. Chongqing, China
3 Aug 1998 ¡ ªSep 2001. Attending doctor and director, in Department of Dermatology, Xin Qiao Hospital of The Third Military Medical University. Chongqing, China
4 Sep 2001-- Vice professor, in Department of Dermatology, The second Affiliated Hospital, College of Medicine, Zhejiang University, Hangzhou 310009, China
RESEARCH EXPERIENCES:
Our major research is on the ability of dermal papillae cells to induce hair follicle regeneration.
In this study, we have adopted cell culture and other techniques to observe the expression of several molecules (such as bFGF, ET-1, SCF) within different passages cultured dermal papillae cells, and the influence of these dermal papillae cells on hair follicle growth and regeneration in organotypic culture and nude mice models of hair follicle regeneration. This is done to provide some experimental evidence of hair regeneration and is aimed for future treatment of alopecia (baldness) using dermal papillae cells by hair transplantation clinics.
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