W
wherehasmyhairgone
member
Well I am glad to be the 1st person to post this subject matter on this Forum. I am of course, as an older male, losing some head hair which I kind of don't want to lose as of course I don't want to admit I am aging LOL.
Anyway this may be of use,touchwood, and would welcome anyone who tries it to please please post any results whether be next week or after a year. The name is SPERMIDINE . Yes strange name but it is a natural substance and a lot can be obtained from Wheatgerm, or can get Supplements cheaply enough. I wont bore you as you can read below article ,but it basically might well have a good effect on Hair Follicles ,and Skin it definitely does. Personally I think this will trun out to be one good supplement.
Oh well I was going to post a link but it wont let me.
These physiologically and clinically relevant data provide the first direct evidence that spermidine is a potent stimulator of human hair growth and a previously unknown modulator of human epithelial stem cell biology.
ALSO SEPARATELY
22.Fashe T, Keinänen T, Grigorenko N, Khomutov A, Jänne J, et al. Cutaneous application of α-Methylspermidine activates the growth of resting hair follicles in mice. Amino Acid. 2009;38(2):583–590. doi: 10.1007/s00726-009-0421-x. [DOI] [PubMed] [Google Scholar]
Recent studies using transgenic animals have revealed a crucial role for polyamines in the development and the growth of skin and hair follicles. In mammals, the growth of hair is characterized by three main cyclic phases of transformation, including a rapid growth phase (anagen), an apoptosis-driven regression phase (catagen) and a relatively quiescent resting phase (telogen). The polyamine pool during the anagen phase is higher than in telogen and catagen phases. In this study, we used alpha-methylspermidine, a metabolically stable polyamine analog, to artificially elevate the polyamine pool during telogen. This manipulation was sufficient to induce hair growth in telogen phase mice after 2 weeks of daily topical application. The application site was characterized by typical features of anagen, such as pigmentation, growing hair follicles, proliferation of follicular keratinocytes and upregulation of beta-catenin. The analog penetrated the protective epidermal layer of the skin and could be detected in dermis. The natural polyamines were partially replaced by the analog in the application site. However, the combined pool of natural spermidine and alpha-methylspermidine exceeded the physiological spermidine pool in telogen phase skin. These results highlight the role of polyamines in hair cycle regulation and show that it is possible to control the process of hair growth using physiologically stable polyamine analogs.
Ive been taking for around 2 months now and will report any effects that my Barber or I notice and please also do likewise for mutual good. I can say my skin looks better.
Anyway this may be of use,touchwood, and would welcome anyone who tries it to please please post any results whether be next week or after a year. The name is SPERMIDINE . Yes strange name but it is a natural substance and a lot can be obtained from Wheatgerm, or can get Supplements cheaply enough. I wont bore you as you can read below article ,but it basically might well have a good effect on Hair Follicles ,and Skin it definitely does. Personally I think this will trun out to be one good supplement.
Oh well I was going to post a link but it wont let me.
Hair Follicle Health
Preliminary studies indicate that spermidine’s role in cellular regeneration may extend to hair follicles. The compound’s ability to promote autophagy and cellular renewal could theoretically support healthy hair growth cycles. Strong clinical evidence for hair growth benefits remains limited. Most current research focuses on spermidine’s internal health benefits rather than cosmetic applications.These physiologically and clinically relevant data provide the first direct evidence that spermidine is a potent stimulator of human hair growth and a previously unknown modulator of human epithelial stem cell biology.
ALSO SEPARATELY
22.Fashe T, Keinänen T, Grigorenko N, Khomutov A, Jänne J, et al. Cutaneous application of α-Methylspermidine activates the growth of resting hair follicles in mice. Amino Acid. 2009;38(2):583–590. doi: 10.1007/s00726-009-0421-x. [DOI] [PubMed] [Google Scholar]
Abstract
Recent studies using transgenic animals have revealed a crucial role for polyamines in the development and the growth of skin and hair follicles. In mammals, the growth of hair is characterized by three main cyclic phases of transformation, including a rapid growth phase (anagen), an apoptosis-driven regression phase (catagen) and a relatively quiescent resting phase (telogen). The polyamine pool during the anagen phase is higher than in telogen and catagen phases. In this study, we used alpha-methylspermidine, a metabolically stable polyamine analog, to artificially elevate the polyamine pool during telogen. This manipulation was sufficient to induce hair growth in telogen phase mice after 2 weeks of daily topical application. The application site was characterized by typical features of anagen, such as pigmentation, growing hair follicles, proliferation of follicular keratinocytes and upregulation of beta-catenin. The analog penetrated the protective epidermal layer of the skin and could be detected in dermis. The natural polyamines were partially replaced by the analog in the application site. However, the combined pool of natural spermidine and alpha-methylspermidine exceeded the physiological spermidine pool in telogen phase skin. These results highlight the role of polyamines in hair cycle regulation and show that it is possible to control the process of hair growth using physiologically stable polyamine analogs.
Ive been taking for around 2 months now and will report any effects that my Barber or I notice and please also do likewise for mutual good. I can say my skin looks better.
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