H
hairtech
member
Here is an informative study comparing the use of the foam 5% minoxidil and the liquid 2% minoxidil. The foam is used once per day. The liquid is applied twice per day. Most clinics knew this would most likely be the conclusion however now we have a clinical study to back the theory.
A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women
· Ulrike Blume-Peytavi, MD, PhD
,
· Kathrin Hillmann, MD
,
· Ekkehart Dietz, PhD
,
· Douglas Canfield
,
· Natalie Garcia Bartels, MD
Accepted 7 September 2010. published online 24 June 2011.
Corrected Proof
Background
Although twice-daily application of propylene glycol containing 2% minoxidil topical solution (MTS) stimulates new hair growth, higher concentrations of minoxidil in a once-daily, propylene glycol free formulation may improve efficacy and reduce unpleasant side effects.
Objective
We sought to compare the efficacy, safety, and acceptability and to show noninferiority of once-daily 5% minoxidil topical foam (MTF) with twice-daily 2% MTS in women with androgenetic alopecia.
Methods
A total of 113 women with androgenetic alopecia were randomized to 24 weeks of treatment with 5% MTF or 2% MTS. The primary efficacy parameter was change from baseline in nonvellus target area hair count at week 24. Secondary end points included change in nonvellus target area hair width, overall efficacy by global photographic review as assessed by treatment-blinded evaluators and the subject herself, adverse events, and participants' assessment of product aesthetics.
Results
After 24 weeks, women randomized to 5% MTF once daily showed noninferior target area hair count and target area hair width and experienced greater, but nonsignificant, improvements in target area hair count, target area hair width, and overall efficacy by global photographic review than those randomized to 2% MTS used twice daily. 5% MTF was significantly superior to 2% MTS in participants' agreement with the treatment does not interfere with styling my hair (P = .002). Women randomized to 5% MTF experienced significantly lower rates of local intolerance (P = .046) especially in pruritus and dandruff compared with 2% MTS.
Limitation
Because of differences in the formulations tested, study participants were not blinded to treatment.
Conclusions
Once-daily 5% MTF is noninferior and as effective for stimulating hair growth as twice-daily 2% MTS in women with androgenetic alopecia and is associated with several aesthetic and practical advantages.
Ronald Shapiro MD
Shapiro Medical Group.
A randomized, single-blind trial of 5% minoxidil foam once daily versus 2% minoxidil solution twice daily in the treatment of androgenetic alopecia in women
· Ulrike Blume-Peytavi, MD, PhD
,
· Kathrin Hillmann, MD
,
· Ekkehart Dietz, PhD
,
· Douglas Canfield
,
· Natalie Garcia Bartels, MD
Accepted 7 September 2010. published online 24 June 2011.
Corrected Proof
Background
Although twice-daily application of propylene glycol containing 2% minoxidil topical solution (MTS) stimulates new hair growth, higher concentrations of minoxidil in a once-daily, propylene glycol free formulation may improve efficacy and reduce unpleasant side effects.
Objective
We sought to compare the efficacy, safety, and acceptability and to show noninferiority of once-daily 5% minoxidil topical foam (MTF) with twice-daily 2% MTS in women with androgenetic alopecia.
Methods
A total of 113 women with androgenetic alopecia were randomized to 24 weeks of treatment with 5% MTF or 2% MTS. The primary efficacy parameter was change from baseline in nonvellus target area hair count at week 24. Secondary end points included change in nonvellus target area hair width, overall efficacy by global photographic review as assessed by treatment-blinded evaluators and the subject herself, adverse events, and participants' assessment of product aesthetics.
Results
After 24 weeks, women randomized to 5% MTF once daily showed noninferior target area hair count and target area hair width and experienced greater, but nonsignificant, improvements in target area hair count, target area hair width, and overall efficacy by global photographic review than those randomized to 2% MTS used twice daily. 5% MTF was significantly superior to 2% MTS in participants' agreement with the treatment does not interfere with styling my hair (P = .002). Women randomized to 5% MTF experienced significantly lower rates of local intolerance (P = .046) especially in pruritus and dandruff compared with 2% MTS.
Limitation
Because of differences in the formulations tested, study participants were not blinded to treatment.
Conclusions
Once-daily 5% MTF is noninferior and as effective for stimulating hair growth as twice-daily 2% MTS in women with androgenetic alopecia and is associated with several aesthetic and practical advantages.
Ronald Shapiro MD
Shapiro Medical Group.
